Endocrine Abstracts

Introduction: Adrenocortical carcinomas (ACCs) are rare; incidence is approximately 1–2 per million population per year. These arefrequently aggressive tumours that may or may not be functional. The primary potentially curative treatment for ACC is surgery with currently mixed opinion among experts regardingadjuvant Mitotane treatment.The Case: 60 years old female was seen in clinic for work up of incidental adrenal mass. ...

Introduction: Adrenocortical carcinomas (ACCs) are rare; incidence is approximately 1–2 per million population per year. These arefrequently aggressive tumours that may or may not be functional. The primary potentially curative treatment for ACC is surgery with currently mixed opinion among experts regardingadjuvant Mitotane treatment.The Case: 60 years old female was seen in clinic for work up of incidental adrenal mass. ...

Aim: To present an unusual case of hypophysitis caused by TNF-α inhibitors and demonstrate the importance of astuteness with regards to endocrine axes testing when clinical circumstances indicate.Case: A 78-year-old gentleman with known fistulating Crohn’s disease (treated with adalimumab and infliximab in the past) presented with vomiting, dizziness, hyponatraemia and hypotension in early December 2018. SST showed he was cortisol-deficient, i...

A 30-year-old lady was initially seen in our clinic with a slight elevated corrected calcium with an elevated parathyroid hormone in March 2021. The elevated calcium [2.58mmol/l(NR: 2.10-2.55)] was first noted in 2018 when she had investigations for easy bruising, fatigue, breathlessness, and weight loss. The symptoms settled on their own and her calcium levels were monitored routinely. She was referred to our clinic when the corrected calcium had increased to 2.69mmol/lwith a...

Introduction: Pituitary apoplexy (PA) remains a rare endocrine diagnosis. Recent UK guidelines have emphasised the lack of evidence in the management of this condition. We present our experience of 23 current cases.In classical acute PA, headache is the commonest presenting symptom. We found that a significant proportion (36%) of patients presented with subacute pituitary tumour apoplexy (SPA) – a term used to describe intra-adenomatous pituitary ha...

Pituitary apoplexy whether due to haemorrhage or infarction remains a rare endocrine diagnosis. Recent UK guidelines have emphasised the lack of published evidence in the management of this condition. We present our experience of 12 current cases (nine males, three females).Eleven cases were managed conservatively (91.6%), one patient required urgent pituitary surgery. None of the above cases required pituitary radiotherapy.Present...

Empty sella is an incidental finding characterised by the herniation of subarachnoid space into the sella turcica with resultant flattening of pituitary gland to varying extent. It was considered benign. But recent reviews have shown its association with some neuroendocrinopathies.Aims and Objectives: To determine if patients with radiological diagnosis of PESS were;1. Referred to Endocrinology team?2. What p...

Case history: Carbimazole, a widely used medication to treat hyperthyroidism, is associated with several well-established side effects. Carbimazole-induced lymphopenia is however rarely reported in the literature. This case focuses on a 57-year-old lady diagnosed with Graves’ Disease (GD) in 2015. She was started on Carbimazole which eventually stabilised her thyroid function; her severe thyroid eye disease precluded definitive treatment with radioiodine however she was r...

Background: We would like to present a case of pancreatic encephalopathy induced by DKA induced hypertriglyceridemia. The triad of acute pancreatitis, hypertriglyceridemia and diabetes is a rare occurrence. Through our case we aim to highlight the importance of making an early diagnosis as a delay in diagnosis can worsen outcomes.Case history: We present the case of a 51 year old Type 2 Diabetic non compliant with her medications who was admitted to the ...

A 28-year-old female presented to ED with one week history of flu-like symptoms, palpitations, increasing breathlessness, and productive cough with copious sputum, of two days duration. There was h/o some weight loss over the last year, with episodic palpitations over the last 8-10 years that increased in frequency over the last one year. She had a family history of hyperthyroidism paternally and maternally. On examination, there was mild lid-lag and proptosis. She was tachypn...